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Bowenoid Papulosis in Men

Sun 05 Feb 2017 18:51:16 +0200

Bowenoid papulosis in men was described in 1977 by Kopf and Bart as papules on the penis. It presents as single or multiple small, red, brown or flesh-coloured spots or patches on the genitals. In males it is a type of penile intraepithelial neoplasia.

Although most cases of Bowenoid papulosis are benign (harmless) a small percentage may transform into invasive squamous cell carcinoma (penile cancer).

Sexually active people may be at risk of getting Bowenoid papulosis and it tends to occur in younger men. As in genital warts, HPV transmission is most often passed through direct skin-to-skin sexual contact. So partners of patients with BP should be screened for other forms of intraepithelial neoplasia (cervical, penile, vulvar and anal).

Treatment options for bowenoid papulosis may include:

surgery
laser surgery
cryosurgery
topical chemotherapy (given as a cream applied to the skin)

5-flurouracil (Adrucil, 5-FU)
podophyllin (Pod-Ben-25, Podofin)
retinoic acid

topical biological therapy

imiquimod (Aldara)
interferon

curettage and electrodessication

In male partners, periodic anogenital examination may be of benefit.

Immunomodulators have been reported as effective treatment for bowenoid papulosis and may lengthen the remission period of lesions.

Bowenoid Papulosis

Wed 01 Feb 2017 10:29:36 +0200

Bowenoid papulosis is now most commonly known to occur on the genitalia of both sexes in sexually active people. Bowenoid papulosis is manifested as papules that are induced virally by human papillomavirus (HPV) and demonstrate a distinctive histopathology (bowenoid dysplasia). Many bowenoid papulosis lesions appear to run a benign course, although a number of case reports associate bowenoid papulosis with malignant invasive transformation (2.6%).

Bowenoid papulosis may be considered to be a transitional state between a genital wart and Bowen disease. The rate of transformation of bowenoid papulosis lesions is unknown. Clearly, bowenoid papulosis lesions have some malignant potential, but they may be treated with locally destructive modalities, sparing the surrounding tissues. Bowenoid papulosis lesions often are multifocal, and patients should be observed for recurrence and for the possibility of invasive or in situ malignancy.

Bowenoid papulosis is an asymptomatic focal epidermal hyperplasia and dysplasia induced by HPV infection (most commonly by HPV 16). The result can appear as a papule or multiple papules that sometimes coalesce, as patches, or as plaques. Histologically, they are composed of scattered atypical cells or full-thickness epidermal atypia that some view as analogous to squamous cell carcinoma in situ. This epidermal atypia is sometimes known as bowenoid dysplasia.

Bowenoid papulosis occurs primarily in young, sexually active adults, with a mean age of 31 years. Because Bowenoid papulosis usually runs a benign course with many cases spontaneously regressing, treatment is often unnecessary. Lesions should be re-examined every 3 to 6 months so that any changes may be picked up early.

Bowenoid Papulosis in Women

Sat 28 Jan 2017 09:22:33 +0200

Bowenoid papulosis is a rare form of intraepithelial neoplasia. This means it is a pre-cancerous skin condition. It presents as single or multiple small, red, brown or flesh-coloured spots or patches on the genitals of males and females. In females it is one type of vulvar intraepithelial neoplasia (VIN). It may occur at any age. The incidence in young women is rising. Although most cases of Bowenoid papulosis are benign (harmless) a small percentage may transform into invasive squamous cell carcinoma (penile or vulvar cancer).

Small red, brown or flesh-coloured flat or warty lesions appear most commonly on the shaft of the penis or labia of females. They may also be present on other parts of the genitals as well as in and around the anus. The condition is usually symptomless but occasionally lesions may become inflamed, itchy and painful. The diagnosis is usually made by skin biopsy.

Bowenoid papulosis tends to spontaneously disappear within several months and if a young woman is pregnant when it is diagnosed it will often disappear after delivery. If it is persistent this is an indication for active treatment because of the chance of developing skin cancer.

Women, who have partners suffering from Bowenoid papulosis, are at higher risk of developing cervical cancer. The risk of carcinomais greatest in women over age of 40. Female partners should be evaluated regularly using Papanicolaou smears.